InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDS2

Summary

InnateDB Protein

IDBP-478067.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDS2

Protein Name

CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000419879

InnateDB Gene

IDBG-51278 (CDS2)

Protein Structure

UniProt Annotation

Function

Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.

Disease Associations

Tissue Specificity

Widely expressed. Expressed in heart, brain and retina, and to a lesser extent in placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269PubMed:9889000}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004605	phosphatidate cytidylyltransferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006655	phosphatidylglycerol biosynthetic process
GO:0016024	CDP-diacylglycerol biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process