Version 5.4
Homo sapiens Protein: NKIRAS2
Summary
InnateDB Protein IDBP-478074.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NKIRAS2
Protein Name NFKB inhibitor interacting Ras-like 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000419929
InnateDB Gene IDBG-50200 (NKIRAS2)
Protein Structure
UniProt Annotation
Function Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF- kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:10657303}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 2 [view]
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005525 GTP binding
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005622 intracellular
Protein Structure and Domains
PDB ID
InterPro IPR013684 Mitochondrial Rho-like
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF08477
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q9NYR9
TrEMBL
UniProt Splice Variant
Entrez Gene 28511
UniGene Hs.632252
RefSeq
HUGO HGNC:17898
OMIM 604497
CCDS
HPRD 07261
IMGT
EMBL
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca