Version 5.4
Homo sapiens Gene: NKIRAS2
Summary
InnateDB Gene IDBG-50200.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NKIRAS2
Gene Name NFKB inhibitor interacting Ras-like 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000168256
Encoded Proteins
IDBP-50202
NFKB inhibitor interacting Ras-like 2
IDBP-50204
NFKB inhibitor interacting Ras-like 2
IDBP-242714
NFKB inhibitor interacting Ras-like 2
IDBP-242718
NFKB inhibitor interacting Ras-like 2
IDBP-242720
NFKB inhibitor interacting Ras-like 2
IDBP-378495
NFKB inhibitor interacting Ras-like 2
IDBP-763962
IDBP-759127
IDBP-758137
IDBP-478074
NFKB inhibitor interacting Ras-like 2
IDBP-758027
IDBP-764313
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20351193
NKIRAS2 is a key inhibitor of NF-kappaB signalling and estradiol represses NF-kappaB activation through the induction of NKIRAS2.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:42011382-42025644
Strand Forward strand
Band q21.2
Transcripts
ENST00000307641 ENSP00000303580
ENST00000316082 ENSP00000312773
ENST00000393885 ENSP00000377463
ENST00000393881 ENSP00000377459
ENST00000393880 ENSP00000377458
ENST00000393879
ENST00000449471 ENSP00000401976
ENST00000485789 ENSP00000466135
ENST00000479407 ENSP00000465633
ENST00000491638 ENSP00000465588
ENST00000462043 ENSP00000419929
ENST00000585955 ENSP00000468081
ENST00000587028
ENST00000587337 ENSP00000468245
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 2 [view]
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005575 cellular_component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000017837
View Gene Order
ENSBTAG00000002657
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL K7ER26
UniProt Splice Variant
Entrez Gene 28511
UniGene Hs.614250 Hs.632252
RefSeq NM_001001349 NM_001144927 NM_001144928 NM_001144929 NM_017595 XM_005257251
HUGO HGNC:17898
OMIM 604497
CCDS CCDS11415 CCDS45679 CCDS45680
HPRD 07261
IMGT
EMBL AC105024
GenPept
RNA Seq Atlas 28511

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca