InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ENPP2

Summary

InnateDB Protein

IDBP-478085.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ENPP2

Protein Name

ectonucleotide pyrophosphatase/phosphodiesterase 2

Synonyms

ATX; ATX-X; AUTOTAXIN; LysoPLD; NPP2; PD-IALPHA; PDNP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000428291

InnateDB Gene

IDBG-33807 (ENPP2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003824	catalytic activity
GO:0004528	phosphodiesterase I activity
GO:0004551	nucleotide diphosphatase activity
GO:0004622	lysophospholipase activity
GO:0005044	scavenger receptor activity
GO:0005509	calcium ion binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0030247	polysaccharide binding
GO:0046872	metal ion binding
GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity

Biological Process

GO:0006796	phosphate-containing compound metabolic process
GO:0006898	receptor-mediated endocytosis
GO:0006928	cellular component movement
GO:0006935	chemotaxis
GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0008152	metabolic process
GO:0009395	phospholipid catabolic process
GO:0030334	regulation of cell migration
GO:0034638	phosphatidylcholine catabolic process
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001212 Somatomedin B domain
IPR001604 DNA/RNA non-specific endonuclease
IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
IPR017850 Alkaline-phosphatase-like, core domain
IPR020436 Somatomedin B, chordata
IPR020821 Extracellular Endonuclease, subunit A

PFAM

PF01033
PF01223
PF01663

PRINTS

PR00022

PIRSF

SMART

SM00201
SM00892
SM00477

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt