Version 5.4
Homo sapiens Protein: PPA2
Summary
InnateDB Protein IDBP-478121.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPA2
Protein Name pyrophosphatase (inorganic) 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000423467
InnateDB Gene IDBG-32751 (PPA2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Mitochondrion {ECO:0000305}.
Disease Associations
Tissue Specificity Detected in brain, gastric carcinoma, lung, ovary, skeletal muscle, umbilical cord blood and a cell line derived from kidney proximal tubule epithelium. {ECO:0000269PubMed:15210126}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004427 inorganic diphosphatase activity
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006796 phosphate-containing compound metabolic process
GO:0010467 gene expression
GO:0071344 diphosphate metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005759 mitochondrial matrix
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR008162 Inorganic pyrophosphatase
PFAM PF00719
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H2U2
PhosphoSite PhosphoSite-Q9H2U2
TrEMBL
UniProt Splice Variant
Entrez Gene 27068
UniGene Hs.635143
RefSeq
HUGO HGNC:28883
OMIM 609988
CCDS
HPRD 18494
IMGT
EMBL AB026722 AC004066 AC106888 AF161473 AF217187 AK000466 AK297096 AL136655 BC022803 BC039462 BC057219
GenPept AAF29088 AAG36781 AAH22803 AAH39462 AAH57219 AAY41040 BAA84701 BAA91184 BAG59609 CAB66590

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca