Version 5.4
Homo sapiens Gene: PPA2
Summary
InnateDB Gene IDBG-32751.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPA2
Gene Name pyrophosphatase (inorganic) 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138777
Encoded Proteins
IDBP-32755
pyrophosphatase (inorganic) 2
IDBP-32759
pyrophosphatase (inorganic) 2
IDBP-32763
pyrophosphatase (inorganic) 2
IDBP-32767
pyrophosphatase (inorganic) 2
IDBP-375386
pyrophosphatase (inorganic) 2
IDBP-478121
pyrophosphatase (inorganic) 2
IDBP-480040
pyrophosphatase (inorganic) 2
IDBP-474378
pyrophosphatase (inorganic) 2
IDBP-476441
pyrophosphatase (inorganic) 2
IDBP-478122
pyrophosphatase (inorganic) 2
IDBP-474781
pyrophosphatase (inorganic) 2
IDBP-474835
pyrophosphatase (inorganic) 2
IDBP-476496
pyrophosphatase (inorganic) 2
IDBP-482356
pyrophosphatase (inorganic) 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is localized to the mitochondrion, is highly similar to members of the inorganic pyrophosphatase (PPase) family, and contains the signature sequence essential for the catalytic activity of PPase. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:105369077-105474081
Strand Reverse strand
Band q24
Transcripts
ENST00000341695 ENSP00000343885
ENST00000348706 ENSP00000313061
ENST00000351450 ENSP00000273977
ENST00000354147 ENSP00000340352
ENST00000432483 ENSP00000389957
ENST00000457404
ENST00000509031 ENSP00000423467
ENST00000513605
ENST00000515567 ENSP00000427375
ENST00000503171
ENST00000510015 ENSP00000423363
ENST00000509426
ENST00000508518 ENSP00000423889
ENST00000514209 ENSP00000424988
ENST00000506815 ENSP00000422405
ENST00000502833
ENST00000504028 ENSP00000421177
ENST00000502596 ENSP00000426347
ENST00000513649 ENSP00000422738
ENST00000499847
ENST00000502610
ENST00000505713
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004427 inorganic diphosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006796 phosphate-containing compound metabolic process
GO:0010467 gene expression
GO:0016311 dephosphorylation
GO:0071344 diphosphate metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028013
View Gene Order
ENSBTAG00000002428
Not yet available
Pathways
NETPATH
REACTOME
REACT_15302
Mitochondrial tRNA aminoacylation pathway
REACT_15482
tRNA Aminoacylation pathway
REACT_71
Gene Expression pathway
KEGG
hsa00190
Oxidative phosphorylation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.635143
RefSeq NM_006903 NM_176866 NM_176867 NM_176869
HUGO
OMIM
CCDS CCDS34043 CCDS3667 CCDS3668 CCDS3669
HPRD 18494
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca