InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OSMR

Summary

InnateDB Protein

IDBP-478381.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OSMR

Protein Name

oncostatin M receptor

Synonyms

OSMRB; PLCA1;

Species

Homo sapiens

Ensembl Protein

ENSP00000422023

InnateDB Gene

IDBG-17615 (OSMR)

Protein Structure

UniProt Annotation

Function

Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. {ECO:0000269PubMed:15184896, ECO:0000269PubMed:8999038}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Amyloidosis, primary localized cutaneous, 1 (PLCA1) [MIM:105250]: A primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. {ECO:0000269PubMed:18179886, ECO:0000269PubMed:19690585}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed at relatively high levels in all neural cells as well as fibroblast, epithelial and a variety of tumor cell lines. {ECO:0000269PubMed:8999038}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	6 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004924	oncostatin-M receptor activity
GO:0005515	protein binding
GO:0019838	growth factor binding

Biological Process

GO:0002675	positive regulation of acute inflammatory response
GO:0007166	cell surface receptor signaling pathway
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0034097	response to cytokine
GO:0038165	oncostatin-M-mediated signaling pathway