Version 5.4
Homo sapiens Protein: KLF8
Summary
InnateDB Protein IDBP-478433.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLF8
Protein Name Kruppel-like factor 8
Synonyms BKLF3; ZNF741;
Species Homo sapiens
Ensembl Protein ENSP00000417303
InnateDB Gene IDBG-72535 (KLF8)
Protein Structure
UniProt Annotation
Function Transcriptional repressor and activator. Binds to CACCC- boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK). {ECO:0000269PubMed:10756197, ECO:0000269PubMed:12820964, ECO:0000269PubMed:16617055}.
Subcellular Localization Nucleus {ECO:0000269PubMed:16617055}.
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:10756197}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95600
PhosphoSite PhosphoSite-O95600
TrEMBL A0A024R9X4
UniProt Splice Variant
Entrez Gene 11279
UniGene Hs.646614
RefSeq NP_009181
HUGO HGNC:6351
OMIM 300286
CCDS CCDS14373
HPRD 02238
IMGT
EMBL AB209004 AK296156 AL050309 BC105130 BC112109 BX322609 BX641066 CH471154 HF546207 HF546208 HF546209 U28282
GenPept AAC99849 AAI05131 AAI12110 BAD92241 BAG58895 CAE46033 CAI41397 CAI42343 CCO02793 CCO02794 CCO02795 EAW93230 EAW93231

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca