Homo sapiens Gene: KLF8
Summary
InnateDB Gene IDBG-72535.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLF8
Gene Name Kruppel-like factor 8
Synonyms BKLF3; ZNF741
Species Homo sapiens
Ensembl Gene ENSG00000102349
Encoded Proteins
Kruppel-like factor 8
Kruppel-like factor 8
Kruppel-like factor 8
Kruppel-like factor 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:56232421-56287889
Strand Forward strand
Band p11.21
Transcripts
ENST00000374928 ENSP00000364063
ENST00000358094 ENSP00000431911
ENST00000476898
ENST00000462627
ENST00000468660 ENSP00000417303
ENST00000624085 ENSP00000485372
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
Signaling events mediated by focal adhesion kinase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.646614
RefSeq NM_001159296 NM_007250 XM_005261977 XM_005261978 XM_005261979 XM_006724575
HUGO
OMIM
CCDS CCDS14373 CCDS55428
HPRD 02238
IMGT
EMBL
GenPept
RNA Seq Atlas