InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NAIP

Summary

InnateDB Protein

IDBP-478479.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NAIP

Protein Name

NLR family, apoptosis inhibitory protein

Synonyms

BIRC1; NLRB1; psiNAIP;

Species

Homo sapiens

Ensembl Protein

ENSP00000428657

InnateDB Gene

IDBG-402309 (NAIP)

Protein Structure

UniProt Annotation

Function

Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor- neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in motor neurons, but not in sensory neurons. Found in liver and placenta, and to a lesser extent in spinal cord.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0017111	nucleoside-triphosphatase activity
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0046872	metal ion binding

Biological Process

GO:0006954	inflammatory response
GO:0007399	nervous system development
GO:0008152	metabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045087	innate immune response

Cellular Component

GO:0005737	cytoplasm
GO:0016323	basolateral plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001370 Baculoviral inhibition of apoptosis protein repeat
IPR003593 AAA+ ATPase domain
IPR007111 NACHT nucleoside triphosphatase
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00653

PRINTS

PIRSF

SMART

SM00238
SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13075