InnateDB Protein
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IDBP-478852.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CGGBP1
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Protein Name
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CGG triplet repeat binding protein 1
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Synonyms
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CGGBP; p20-CGGBP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000418769
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InnateDB Gene
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IDBG-115757 (CGGBP1)
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Protein Structure
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Function |
Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter. {ECO:0000269PubMed:9201980}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:9201980}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Highly expressed in placenta, thymus, lymph nodes, cerebellum and cerebral cortex. Low expression in other regions of the brain. {ECO:0000269PubMed:14667814}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0000977
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RNA polymerase II regulatory region sequence-specific DNA binding
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GO:0001227
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RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
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GO:0003690
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double-stranded DNA binding
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006351
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transcription, DNA-templated
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UFW8
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PhosphoSite |
PhosphoSite-Q9UFW8
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TrEMBL |
C9JUJ0
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UniProt Splice Variant |
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Entrez Gene |
8545
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UniGene |
Hs.622366
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RefSeq |
NP_001182237
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HUGO |
HGNC:1888
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OMIM |
603363
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CCDS |
CCDS43111
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HPRD |
04529
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IMGT |
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EMBL |
AC119733
AC128650
AF094481
AJ000258
AL117392
AM393707
BC052980
CH471110
CR456854
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GenPept |
AAD04161
AAH52980
CAA03974
CAB55894
CAG33135
CAL38583
EAW68863
EAW68864
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