InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATG10

Summary

InnateDB Protein

IDBP-478898.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATG10

Protein Name

ATG10 autophagy related 10 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000425182

InnateDB Gene

IDBG-32027 (ATG10)

Protein Structure

UniProt Annotation

Function

E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis. {ECO:0000250, ECO:0000269PubMed:21367888}.

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0019777	Atg12 ligase activity

Biological Process

GO:0006497	protein lipidation
GO:0006914	autophagy
GO:0015031	protein transport
GO:0031401	positive regulation of protein modification process
GO:0032446	protein modification by small protein conjugation
GO:0034263	autophagy in response to ER overload