InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRPC7

Summary

InnateDB Protein

IDBP-478931.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRPC7

Protein Name

transient receptor potential cation channel, subfamily C, member 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000426070

InnateDB Gene

IDBG-45985 (TRPC7)

Protein Structure

UniProt Annotation

Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:21402151}; Multi-pass membrane protein {ECO:0000269PubMed:21402151}. Nucleus envelope {ECO:0000269PubMed:21402151}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005262	calcium channel activity
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0006828	manganese ion transport
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0034220	ion transmembrane transport
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005635	nuclear envelope
GO:0005801	cis-Golgi network
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR002110 Ankyrin repeat
IPR002153 Transient receptor potential channel, canonical
IPR004729 Transient receptor potential channel
IPR005463 Transient receptor potential channel, canonical 7
IPR005821 Ion transport domain
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR013555 Transient receptor ion channel domain
IPR016024 Armadillo-type fold
IPR020683 Ankyrin repeat-containing domain

PFAM