InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ALKBH4

Summary

InnateDB Protein

IDBP-478947.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALKBH4

Protein Name

alkB, alkylation repair homolog 4 (E. coli)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000420362

InnateDB Gene

IDBG-33587 (ALKBH4)

Protein Structure

UniProt Annotation

Function

Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. May be involved in transcription regulation. {ECO:0000269PubMed:21166655, ECO:0000269PubMed:23673617}.

Subcellular Localization

Cytoplasm. Nucleus. Midbody. Note=Associates with the contractile ring and midbody.

Disease Associations

Tissue Specificity

Widely expressed, with highest expression in pancreas, ovary and spleen. {ECO:0000269PubMed:17979886}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0032451	demethylase activity
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006482	protein demethylation
GO:0031032	actomyosin structure organization
GO:0036090	cleavage furrow ingression
GO:0055114	oxidation-reduction process