Homo sapiens Protein: SPOCK3
Summary
InnateDB Protein IDBP-479052.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPOCK3
Protein Name sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000423421
InnateDB Gene IDBG-43742 (SPOCK3)
Protein Structure
UniProt Annotation
Function May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion.
Subcellular Localization Secreted, extracellular space, extracellular matrix.
Disease Associations
Tissue Specificity Expressed in brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008191 metalloendopeptidase inhibitor activity
Biological Process
GO:0007165 signal transduction
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0031012 extracellular matrix
Protein Structure and Domains
PDB ID
InterPro IPR000716 Thyroglobulin type-1
IPR002350 Kazal domain
IPR019577 SPARC/Testican, calcium-binding domain
PFAM PF00086
PF00050
PF07648
PF10591
PRINTS
PIRSF
SMART SM00211
SM00280
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BQ16
PhosphoSite PhosphoSite-Q9BQ16
TrEMBL Q4W5S3
UniProt Splice Variant
Entrez Gene 50859
UniGene Hs.710186
RefSeq
HUGO HGNC:13565
OMIM 607989
CCDS
HPRD 12147
IMGT
EMBL AB056866 AC010103 AC020599 AC023492 AC107210 AJ001454 AK091078 AK294637 AK295015 AK295281 AK295407 AK296291 AK313042 AY358973 BC000460 BC003017 BC013983 CH471056
GenPept AAH00460 AAH03017 AAH13983 AAQ89332 AAY40960 AAY40993 BAB64908 BAG35874 BAG52279 BAG57816 BAG58075 BAG58265 BAG58358 BAG58995 CAA04775 EAX04811