Version 5.4
Homo sapiens Protein: PTPN20A
Summary
InnateDB Protein IDBP-479112.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPN20A
Protein Name protein tyrosine phosphatase, non-receptor type 20A
Synonyms bA142I17.1; bA42B19.1; CT126; hPTPN20; PTPN20A;
Species Homo sapiens
Ensembl Protein ENSP00000424491
InnateDB Gene IDBG-72304 (PTPN20A)
Protein Structure
UniProt Annotation
Function Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates.
Subcellular Localization Nucleus {ECO:0000269PubMed:15790311}. Cytoplasm {ECO:0000269PubMed:15790311}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:15790311}. Note=Colocalizes with the microtubule-organizing center and intracellular membrane compartments.
Disease Associations
Tissue Specificity Present in many cell lines (at protein level). Widely expressed. {ECO:0000269PubMed:15790311}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005874 microtubule
Protein Structure and Domains
PDB ID
InterPro IPR029021 Protein-tyrosine phosphatase-like
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q4JDL3
PhosphoSite PhosphoSite-Q4JDL3
TrEMBL Q5T1G4
UniProt Splice Variant
Entrez Gene 26095
UniGene Hs.440733
RefSeq
HUGO HGNC:23422
OMIM 610631
CCDS CCDS73115
HPRD
IMGT
EMBL AL358791 AL450334 AL672108 AY704141 AY704142 AY704143 AY704144 AY704145 AY704146 AY704147 AY704148 AY704149 AY704150 AY704151 AY704152 AY704153 AY704154 AY704158 AY753191 BC093750 BC113473 BC143394 BC171725 BX005072
GenPept AAH93750 AAI13474 AAI43395 AAI71725 AAW28780 AAW28781 AAW28782 AAW28783 AAW28784 AAW28785 AAW28786 AAW28787 AAW28788 AAW28789 AAW28790 AAW28791 AAW28792 AAW28793 AAW28797 AAW88572 CAI12199 CAI12200 CAI14088 CAI14090 CAI15684 CAI15685 CAI23640 CAI23642

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca