Homo sapiens Gene: PTPN20A
Summary
InnateDB Gene IDBG-72304.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPN20A
Gene Name protein tyrosine phosphatase, non-receptor type 20A
Synonyms bA142I17.1; bA42B19.1; CT126; hPTPN20; PTPN20A;
Species Homo sapiens
Ensembl Gene ENSG00000204179
Encoded Proteins
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20A
Protein Structure
Entrez Gene
Summary The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Many protein tyrosine phosphatases have been shown to regulate fundamental cellular processes and several are mutated in human diseases. Chromosome 10q contains a segmental duplication resulting in multiple copies of the protein tyrosine phosphatase, non-receptor type 20 gene. The two nearly identical copies are designated as PTPN20A and PTPN20B. A third copy is only partially duplicated and contains a pseudogene, designated as PTPN20C. This gene encodes the more centromeric copy, PTPN20A. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Many protein tyrosine phosphatases have been shown to regulate fundamental cellular processes and several are mutated in human diseases. Chromosome 10q contains a segmental duplication resulting in multiple copies of the protein tyrosine phosphatase, non-receptor type 20 gene. The two nearly identical copies are designated as PTPN20A and PTPN20B. A third copy is only partially duplicated and contains a pseudogene, designated as PTPN20C. This gene encodes the more telomeric copy, PTPN20B. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Many protein tyrosine phosphatases have been shown to regulate fundamental cellular processes. The encoded protein appears to be targeted to sites of actin polymerization. A pseudogene of this gene has been defined on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:46911396-47002488
Strand Forward strand
Band q11.22
Transcripts
ENST00000374346 ENSP00000363466
ENST00000374342 ENSP00000363462
ENST00000374339 ENSP00000363459
ENST00000374218 ENSP00000363335
ENST00000395727 ENSP00000379077
ENST00000395725 ENSP00000379075
ENST00000395722 ENSP00000379072
ENST00000395721 ENSP00000379071
ENST00000437863 ENSP00000403444
ENST00000417004 ENSP00000396009
ENST00000509900 ENSP00000423819
ENST00000503851 ENSP00000427676
ENST00000506080 ENSP00000421921
ENST00000513266 ENSP00000422839
ENST00000502705 ENSP00000420995
ENST00000505814 ENSP00000426355
ENST00000509774 ENSP00000425362
ENST00000508602 ENSP00000424491
ENST00000511769 ENSP00000424283
ENST00000513159 ENSP00000477675
ENST00000509599 ENSP00000425012
ENST00000508715 ENSP00000480504
ENST00000510335 ENSP00000421453
ENST00000513156 ENSP00000425912
ENST00000502254 ENSP00000421404
ENST00000513756 ENSP00000479990
ENST00000508357 ENSP00000426681
ENST00000466912
ENST00000506881 ENSP00000422384
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005874 microtubule
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Cross-References
SwissProt Q4JDL3
TrEMBL D6RC68 D6RFJ1 Q4JDK3 Q5T1G4
UniProt Splice Variant
Entrez Gene 26095
UniGene Hs.440733
RefSeq NM_001042357 NM_001042358 NM_001042359 NM_001042360 NM_001042361 NM_001042362 NM_001042363 NM_001042364 NM_001042365 NM_015605 XM_005270315 XM_005277652 XM_006717755 XM_006717756
HUGO HGNC:23422
OMIM 610630 610631
CCDS CCDS73105 CCDS73106 CCDS73107 CCDS73108 CCDS73109 CCDS73110 CCDS73111 CCDS73114 CCDS73115 CCDS73116
HPRD
IMGT
EMBL AL358791 AL450334 AL672108 AY704141 AY704142 AY704143 AY704144 AY704145 AY704146 AY704147 AY704148 AY704149 AY704150 AY704151 AY704152 AY704153 AY704154 AY704155 AY704156 AY704157 AY704158 AY753191 BC093750 BC113473 BC143394 BC171725 BX005072
GenPept AAH93750 AAI13474 AAI43395 AAI71725 AAW28780 AAW28781 AAW28782 AAW28783 AAW28784 AAW28785 AAW28786 AAW28787 AAW28788 AAW28789 AAW28790 AAW28791 AAW28792 AAW28793 AAW28794 AAW28795 AAW28796 AAW28797 AAW88572 CAI12199 CAI12200 CAI14088 CAI14090 CAI15684 CAI15685 CAI23640 CAI23642
ImmGen PTPN20A (murine)
RNA Seq Atlas 102725179 26095