Homo sapiens Gene: PTPN20A

Summary
InnateDB Gene IDBG-72304.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol PTPN20A
Gene Name protein tyrosine phosphatase, non-receptor type 20A
Synonyms bA142I17.1; CT126; hPTPN20; PTPN20B
Species Homo sapiens
Ensembl Gene ENSG00000204179
Encoded Proteins
IDBP-72306 protein tyrosine phosphatase, non-receptor type 20A
IDBP-72308 protein tyrosine phosphatase, non-receptor type 20A
IDBP-72314 protein tyrosine phosphatase, non-receptor type 20A
IDBP-73373 protein tyrosine phosphatase, non-receptor type 20A
IDBP-238940 protein tyrosine phosphatase, non-receptor type 20A
IDBP-238942 protein tyrosine phosphatase, non-receptor type 20A
IDBP-238944 protein tyrosine phosphatase, non-receptor type 20A
IDBP-238946 protein tyrosine phosphatase, non-receptor type 20A
IDBP-374194 protein tyrosine phosphatase, non-receptor type 20A
IDBP-374197 protein tyrosine phosphatase, non-receptor type 20A
IDBP-480137 protein tyrosine phosphatase, non-receptor type 20A
IDBP-474972 protein tyrosine phosphatase, non-receptor type 20A
IDBP-479684 protein tyrosine phosphatase, non-receptor type 20A
IDBP-480353 protein tyrosine phosphatase, non-receptor type 20A
IDBP-480755 protein tyrosine phosphatase, non-receptor type 20A
IDBP-482509 protein tyrosine phosphatase, non-receptor type 20A
IDBP-484993 protein tyrosine phosphatase, non-receptor type 20A
IDBP-479112 protein tyrosine phosphatase, non-receptor type 20A
IDBP-484537 protein tyrosine phosphatase, non-receptor type 20A
IDBP-474687 protein tyrosine phosphatase, non-receptor type 20A
IDBP-478752 protein tyrosine phosphatase, non-receptor type 20A
IDBP-481018 protein tyrosine phosphatase, non-receptor type 20A
IDBP-476564 protein tyrosine phosphatase, non-receptor type 20A
IDBP-485316 protein tyrosine phosphatase, non-receptor type 20A
IDBP-474434 protein tyrosine phosphatase, non-receptor type 20A
Entrez Gene
Summary The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Many protein tyrosine phosphatases have been shown to regulate fundamental cellular processes and several are mutated in human diseases. Chromosome 10q contains a segmental duplication resulting in multiple copies of the protein tyrosine phosphatase, non-receptor type 20 gene. The two nearly identical copies are designated as PTPN20A and PTPN20B. A third copy is only partially duplicated and contains a pseudogene, designated as PTPN20C. This gene encodes the more centromeric copy, PTPN20A. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Many protein tyrosine phosphatases have been shown to regulate fundamental cellular processes and several are mutated in human diseases. Chromosome 10q contains a segmental duplication resulting in multiple copies of the protein tyrosine phosphatase, non-receptor type 20 gene. The two nearly identical copies are designated as PTPN20A and PTPN20B. A third copy is only partially duplicated and contains a pseudogene, designated as PTPN20C. This gene encodes the more telomeric copy, PTPN20B. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10: 46549955-46641045
Strand Reverse strand
Band q11.22
Transcripts
ENST00000374346  ENSP00000363466
ENST00000374342  ENSP00000363462
ENST00000374340 
ENST00000246887 
ENST00000374339  ENSP00000363459
ENST00000374218  ENSP00000363335
ENST00000395727  ENSP00000379077
ENST00000395725  ENSP00000379075
ENST00000395722  ENSP00000379072
ENST00000395721  ENSP00000379071
ENST00000437863  ENSP00000403444
ENST00000417004  ENSP00000396009
ENST00000509181 
ENST00000509900  ENSP00000423819
ENST00000503851  ENSP00000427676
ENST00000506080  ENSP00000421921
ENST00000513266  ENSP00000422839
ENST00000502705  ENSP00000420995
ENST00000505814  ENSP00000426355
ENST00000509774  ENSP00000425362
ENST00000508602  ENSP00000424491
ENST00000511769  ENSP00000424283
ENST00000513159 
ENST00000509599  ENSP00000425012
ENST00000508715 
ENST00000510335  ENSP00000421453
ENST00000513156  ENSP00000425912
ENST00000502254  ENSP00000421404
ENST00000513756 
ENST00000508357  ENSP00000426681
ENST00000466912 
ENST00000506881  ENSP00000422384
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005815 microtubule organizing center
GO:0005874 microtubule
Orthologs
Species
Mus musculus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000021940 RBBH Low Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q4JDL3 
TrEMBL D6RC68 D6RF36 G8JLF7 G8JLF9 Q4JDK3 Q5T1G4
UniProt Splice Variant
Entrez Gene 26095  653129 
UniGene Hs.440733
RefSeq NM_001042387  NM_001042389  NM_001042390  NM_001042391  NM_001042392  NM_001042393  NM_001042394  NM_001042395  NM_001042396 
HUGO 23422 
OMIM 610630 610631
CCDS CCDS31189  CCDS31190  CCDS31191  CCDS41505  CCDS41506  CCDS41507  CCDS41508  CCDS53530  CCDS53531 
HPRD
IMGT
EMBL AL358791 AL450334 AL672108 AY704141 AY704142 AY704143 AY704144 AY704145 AY704146 AY704147 AY704148 AY704149 AY704150 AY704151 AY704152 AY704153 AY704154 AY704155 AY704156 AY704157 AY704158 AY753191 BC093750 BC113473 BC143394 BC171725 BX005072
GenPept AAH93750  AAI13474  AAI43395  AAI71725  AAW28780  AAW28781  AAW28782  AAW28783  AAW28784  AAW28785  AAW28786  AAW28787  AAW28788  AAW28789  AAW28790  AAW28791  AAW28792  AAW28793  AAW28794  AAW28795  AAW28796  AAW28797  AAW88572  CAI12199  CAI12200  CAI14088  CAI14089  CAI14090  CAI15684  CAI15685  CAI23640  CAI23642 
ImmGen PTPN20A (murine) 
RNA Seq Atlas 26095  653129