InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IPO5

Summary

InnateDB Protein

IDBP-479225.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IPO5

Protein Name

importin 5

Synonyms

IMB3; imp5; KPNB3; Pse1; RANBP5;

Species

Homo sapiens

Ensembl Protein

ENSP00000418393

InnateDB Gene

IDBG-44066 (IPO5)

Protein Structure

UniProt Annotation

Function

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000250, ECO:0000269PubMed:9687515}.

Subcellular Localization

Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Nucleus; nuclear rim. Found particularly in the nuclear rim and nucleolus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	67 [view]
Protein-Protein	67 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005095	GTPase inhibitor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0008536	Ran GTPase binding
GO:0008565	protein transporter activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006607	NLS-bearing protein import into nucleus
GO:0006610	ribosomal protein import into nucleus
GO:0006886	intracellular protein transport
GO:0016032	viral process
GO:0042307	positive regulation of protein import into nucleus
GO:0043086	negative regulation of catalytic activity
GO:0071230	cellular response to amino acid stimulus

Cellular Component

GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0031965	nuclear membrane
GO:0043231	intracellular membrane-bounded organelle