InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLBP

Summary

InnateDB Protein

IDBP-479479.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLBP

Protein Name

stem-loop binding protein

Synonyms

HBP;

Species

Homo sapiens

Ensembl Protein

ENSP00000417686

InnateDB Gene

IDBG-6789 (SLBP)

Protein Structure

UniProt Annotation

Function

RNA-binding protein involved in the histone pre-mRNA processing. Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery. Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression. Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis. Binds to the 5' side of the stem-loop structure of histone pre-mRNAs. {ECO:0000269PubMed:12588979, ECO:0000269PubMed:19155325}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Polyribosome- associated. Localizes predominantly in the nucleus at the G1/G2 phases and the beginning of S phase. Through the S phase, partially redistributes to the cytoplasm. Binding to histone mRNA is necessary for cytoplasmic localization. Shuttles between the nucleus and the cytoplasm. Imported in the nucleus by the Importin alpha/Importin beta receptor.

Disease Associations

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0071207	histone pre-mRNA stem-loop binding
GO:0071208	histone pre-mRNA DCP binding

Biological Process

GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006398	histone mRNA 3'-end processing
GO:0006406	mRNA export from nucleus
GO:0008334	histone mRNA metabolic process
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing
GO:0033260	nuclear cell cycle DNA replication
GO:0051028	mRNA transport

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030529	ribonucleoprotein complex
GO:0071204	histone pre-mRNA 3'end processing complex