InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KHDRBS1

Summary

InnateDB Protein

IDBP-479623.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KHDRBS1

Protein Name

KH domain containing, RNA binding, signal transduction associated 1

Synonyms

p62; p68; Sam68;

Species

Homo sapiens

Ensembl Protein

ENSP00000417731

InnateDB Gene

IDBG-95540 (KHDRBS1)

Protein Structure

UniProt Annotation

Function

Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain- containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). {ECO:0000269PubMed:22253824}.Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. {ECO:0000269PubMed:9013542}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:1374686}. Membrane {ECO:0000269PubMed:1374686}.

Disease Associations

Tissue Specificity

Ubiquitously expressed in all tissue examined. Isoform 1 is expressed at lower levels in brain, skeletal muscle, and liver whereas isoform 3 is intensified in skeletal muscle and in liver. {ECO:0000269PubMed:9013542}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 198 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	198 [view]
Protein-Protein	192 [view]
Protein-DNA	3 [view]
Protein-RNA	2 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding
GO:0008143	poly(A) binding
GO:0008266	poly(U) RNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0006351	transcription, DNA-templated
GO:0006397	mRNA processing
GO:0007050	cell cycle arrest
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0008283	cell proliferation
GO:0009967	positive regulation of signal transduction
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045948	positive regulation of translational initiation
GO:0046831	regulation of RNA export from nucleus
GO:0046833	positive regulation of RNA export from nucleus