InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AKR1C3

Summary

InnateDB Protein

IDBP-47966.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKR1C3

Protein Name

aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)

Synonyms

DD3; DDX; HA1753; HAKRB; HAKRe; hluPGFS; HSD17B5; PGFS;

Species

Homo sapiens

Ensembl Protein

ENSP00000369927

InnateDB Gene

IDBG-47964 (AKR1C3)

Protein Structure

UniProt Annotation

Function

Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta- PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate. {ECO:0000269PubMed:10557352, ECO:0000269PubMed:10622721, ECO:0000269PubMed:11165022, ECO:0000269PubMed:7650035, ECO:0000269PubMed:9415401, ECO:0000269PubMed:9927279}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001758	retinal dehydrogenase activity
GO:0004032	alditol:NADP+ 1-oxidoreductase activity
GO:0004033	aldo-keto reductase (NADP) activity
GO:0004745	retinol dehydrogenase activity
GO:0004958	prostaglandin F receptor activity
GO:0016491	oxidoreductase activity
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0018636	phenanthrene 9,10-monooxygenase activity
GO:0035410	dihydrotestosterone 17-beta-dehydrogenase activity
GO:0036131	prostaglandin D2 11-ketoreductase activity
GO:0045550	geranylgeranyl reductase activity
GO:0045703	ketoreductase activity
GO:0047017	prostaglandin-F synthase activity
GO:0047020	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
GO:0047023	androsterone dehydrogenase activity
GO:0047035	testosterone dehydrogenase (NAD+) activity
GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity
GO:0047086	ketosteroid monooxygenase activity
GO:0047115	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
GO:0047718	indanol dehydrogenase activity
GO:0047787	delta4-3-oxosteroid 5beta-reductase activity

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0001523	retinoid metabolic process
GO:0006693	prostaglandin metabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007584	response to nutrient
GO:0007603	phototransduction, visible light
GO:0008202	steroid metabolic process
GO:0008284	positive regulation of cell proliferation
GO:0008584	male gonad development
GO:0009267	cellular response to starvation
GO:0010942	positive regulation of cell death
GO:0016488	farnesol catabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019371	cyclooxygenase pathway
GO:0030216	keratinocyte differentiation
GO:0034614	cellular response to reactive oxygen species
GO:0034694	response to prostaglandin stimulus
GO:0042448	progesterone metabolic process
GO:0042574	retinal metabolic process
GO:0044259	multicellular organismal macromolecule metabolic process
GO:0044281	small molecule metabolic process
GO:0044597	daunorubicin metabolic process
GO:0044598	doxorubicin metabolic process
GO:0048385	regulation of retinoic acid receptor signaling pathway
GO:0051897	positive regulation of protein kinase B signaling
GO:0055114	oxidation-reduction process
GO:0061370	testosterone biosynthetic process
GO:0070293	renal absorption
GO:0071276	cellular response to cadmium ion
GO:0071277	cellular response to calcium ion
GO:0071379	cellular response to prostaglandin stimulus
GO:0071384	cellular response to corticosteroid stimulus
GO:0071395	cellular response to jasmonic acid stimulus
GO:1900053	negative regulation of retinoic acid biosynthetic process
GO:2000224	regulation of testosterone biosynthetic process
GO:2000353	positive regulation of endothelial cell apoptotic process
GO:2000379	positive regulation of reactive oxygen species metabolic process