InnateDB Protein
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IDBP-479699.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FNIP1
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Protein Name
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folliculin interacting protein 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000421985
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InnateDB Gene
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IDBG-281600 (FNIP1)
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Protein Structure
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Function |
May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. {ECO:0000269PubMed:17028174, ECO:0000269PubMed:18663353}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:18663353}. Note=Colocalizes with FLCN in the cytoplasm.
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Disease Associations |
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Tissue Specificity |
Strong expression is found in the heart, liver placenta, muscle, nasal mucosa, salivary gland and uvula and moderate expression in kidney and lung. Higher levels detected in clear cell renal cell carcinoma (RCC) and chromophobe RCC than in normal kidney tissue. {ECO:0000269PubMed:17028174, ECO:0000269PubMed:18403135}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0001932
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regulation of protein phosphorylation
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GO:0001934
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positive regulation of protein phosphorylation
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GO:0002327
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immature B cell differentiation
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GO:0002904
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positive regulation of B cell apoptotic process
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GO:0009267
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cellular response to starvation
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GO:0031929
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TOR signaling
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GO:0032007
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negative regulation of TOR signaling
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GO:0033138
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positive regulation of peptidyl-serine phosphorylation
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GO:0043154
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negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
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GO:0043547
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positive regulation of GTPase activity
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GO:2000973
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regulation of pro-B cell differentiation
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8TF40
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PhosphoSite |
PhosphoSite-Q8TF40
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TrEMBL |
B3KX44
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UniProt Splice Variant |
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Entrez Gene |
96459
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UniGene |
Hs.591273
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RefSeq |
NP_588613
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HUGO |
HGNC:29418
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OMIM |
610594
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CCDS |
CCDS34227
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HPRD |
17233
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IMGT |
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EMBL |
AB075841
AC004227
AC004622
AC005593
AC008497
AC008695
AC026754
AK126675
AL832008
BC001956
DQ145719
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GenPept |
AAH01956
AAZ65854
BAB85547
BAG54356
CAD91145
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