Version 5.4
Homo sapiens Protein: ANAPC13
Summary
InnateDB Protein IDBP-479795.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANAPC13
Protein Name anaphase promoting complex subunit 13
Synonyms APC13; SWM1;
Species Homo sapiens
Ensembl Protein ENSP00000427327
InnateDB Gene IDBG-57556 (ANAPC13)
Protein Structure
UniProt Annotation
Function Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269PubMed:15060174, ECO:0000269PubMed:18485873}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
Experimentally validated
Total 28 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007067 mitotic nuclear division
GO:0070979 protein K11-linked ubiquitination
Cellular Component
GO:0005680 anaphase-promoting complex
Protein Structure and Domains
PDB ID
InterPro IPR008401 Apc13p
PFAM PF05839
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BS18
PhosphoSite PhosphoSite-Q9BS18
TrEMBL A8K3Z6
UniProt Splice Variant
Entrez Gene 25847
UniGene Hs.106909
RefSeq NP_001229304
HUGO HGNC:24540
OMIM 614484
CCDS CCDS3085
HPRD 08531
IMGT
EMBL AK290761 AL050051 BC005398 CH471052
GenPept AAH05398 BAF83450 CAB43251 EAW79143 EAW79145 EAW79147 EAW79149

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca