InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLCN3

Summary

InnateDB Protein

IDBP-479801.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLCN3

Protein Name

chloride channel 3

Synonyms

ClC-3; CLC3;

Species

Homo sapiens

Ensembl Protein

ENSP00000424603

InnateDB Gene

IDBG-44331 (CLCN3)

Protein Structure

UniProt Annotation

Function

Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory. {ECO:0000269PubMed:11967229}.

Subcellular Localization

Isoform 1: Membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Isoform 1 is localized mainly in early and late endosomes.Isoform 2: Membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Isoform 2 partially colocalized with isoform 1 but is mainly enriched in the Golgi.

Disease Associations

Tissue Specificity

Expressed primarily in tissues derived from neuroectoderm. Within the brain, its expression is particularly evident in the hippocampus, olfactory cortex, and olfactory bulb. Highly expressed in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Also expressed in tracheal and alveolar epithelial cells, and intima and media of the pulmonary vessels. Expressed in bronchus and colon (at protein level). {ECO:0000269PubMed:10198195, ECO:0000269PubMed:11967229, ECO:0000269PubMed:12471024}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	7 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005247	voltage-gated chloride channel activity
GO:0005254	chloride channel activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015297	antiporter activity
GO:0030165	PDZ domain binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006810	transport
GO:0006821	chloride transport
GO:0006885	regulation of pH
GO:0034220	ion transmembrane transport
GO:0044070	regulation of anion transport
GO:0048388	endosomal lumen acidification
GO:0055085	transmembrane transport
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0000139	Golgi membrane
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005794	Golgi apparatus
GO:0009986	cell surface
GO:0012506	vesicle membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030658	transport vesicle membrane
GO:0031901	early endosome membrane
GO:0031902	late endosome membrane