InnateDB Protein
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IDBP-479843.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RBM5
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Protein Name
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RNA binding motif protein 5
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Synonyms
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G15; LUCA15; RMB5;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000419534
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InnateDB Gene
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IDBG-35856 (RBM5)
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Protein Structure
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Function |
Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis. {ECO:0000269PubMed:10949932, ECO:0000269PubMed:12207175, ECO:0000269PubMed:12581154, ECO:0000269PubMed:15192330, ECO:0000269PubMed:16585163, ECO:0000269PubMed:18840686, ECO:0000269PubMed:18851835}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:18851835}.
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Disease Associations |
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Tissue Specificity |
Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukemic cell lines.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
35
[view]
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Protein-Protein |
35
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P52756
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PhosphoSite |
PhosphoSite-P52756
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TrEMBL |
E1CJT4
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UniProt Splice Variant |
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Entrez Gene |
10181
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UniGene |
Hs.735496
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RefSeq |
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HUGO |
HGNC:9902
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OMIM |
606884
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CCDS |
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HPRD |
06052
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IMGT |
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EMBL |
AB586690
AC104450
AF091263
AF103802
AF107493
AK297249
AK297445
AK302766
AK314032
CH471055
U23946
U73168
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GenPept |
AAA99715
AAB42216
AAD04159
AAF02422
AAF99551
BAG36742
BAG59728
BAG59871
BAG63975
BAJ19019
EAW65040
EAW65041
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