InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EBF2

Summary

InnateDB Protein

IDBP-479915.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EBF2

Protein Name

early B-cell factor 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000430241

InnateDB Gene

IDBG-281524 (EBF2)

Protein Structure

UniProt Annotation

Function

Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt- responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0046983	protein dimerization activity

Biological Process

GO:0001709	cell fate determination
GO:0006351	transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0035563	positive regulation of chromatin binding
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050873	brown fat cell differentiation
GO:0060612	adipose tissue development