Version 5.4
Homo sapiens Gene: EBF2
Summary
InnateDB Gene IDBG-281524.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EBF2
Gene Name early B-cell factor 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000221818
Encoded Proteins
IDBP-294862
early B-cell factor 2
IDBP-479915
early B-cell factor 2
IDBP-588850
early B-cell factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the COE (Collier/Olf/EBF) family of non-basic, helix-loop-helix transcription factors that have a well conserved DNA binding domain. The COE family proteins play an important role in variety of developmental processes. Studies in mouse suggest that this gene may be involved in the differentiation of osteoblasts. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:25841730-26045397
Strand Reverse strand
Band p21.2
Transcripts
ENST00000408929 ENSP00000386178
ENST00000520164 ENSP00000430241
ENST00000517825
ENST00000535548 ENSP00000437909
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0046983 protein dimerization activity
Biological Process
GO:0001709 cell fate determination
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0035563 positive regulation of chromatin binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050873 brown fat cell differentiation
GO:0060612 adipose tissue development
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000022053
View Gene Order
Cross-References
SwissProt Q9HAK2
TrEMBL B2RNT0 B7Z934 F5H645
UniProt Splice Variant
Entrez Gene 64641
UniGene Hs.491292
RefSeq NM_022659
HUGO HGNC:19090
OMIM 609934
CCDS CCDS43726
HPRD
IMGT
EMBL AC023566 AC090103 AK021562 AK304372 BC069665 BC069726 BC069747 BC069768 BC074794 BC113478 BC113504 BC137106 BC137107
GenPept AAH69665 AAH69726 AAH69747 AAH69768 AAH74794 AAI13479 AAI13505 AAI37107 AAI37108 BAB13843 BAH14170
RNA Seq Atlas 64641

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca