InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NUDT5

Summary

InnateDB Protein

IDBP-480002.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUDT5

Protein Name

nudix (nucleoside diphosphate linked moiety X)-type motif 5

Synonyms

hYSAH1; YSA1; YSA1H; YSAH1;

Species

Homo sapiens

Ensembl Protein

ENSP00000419628

InnateDB Gene

IDBG-53844 (NUDT5)

Protein Structure

UniProt Annotation

Function

Hydrolyzes with similar activities ADP-ribose ADP- mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. {ECO:0000269PubMed:17052728}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed. Most abundant in liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0016787	hydrolase activity
GO:0017110	nucleoside-diphosphatase activity
GO:0019144	ADP-sugar diphosphatase activity
GO:0030515	snoRNA binding
GO:0047631	ADP-ribose diphosphatase activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0009117	nucleotide metabolic process
GO:0009191	ribonucleoside diphosphate catabolic process
GO:0019303	D-ribose catabolic process
GO:0034656	nucleobase-containing small molecule catabolic process
GO:0044281	small molecule metabolic process
GO:0055086	nucleobase-containing small molecule metabolic process