Version 5.4
Homo sapiens Protein: COX18
Summary
InnateDB Protein IDBP-480287.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COX18
Protein Name COX18 cytochrome c oxidase assembly homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000424978
InnateDB Gene IDBG-23258 (COX18)
Protein Structure
UniProt Annotation
Function Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space. {ECO:0000269PubMed:16911509}.
Subcellular Localization Mitochondrion inner membrane {ECO:0000269PubMed:16212937}; Multi-pass membrane protein {ECO:0000269PubMed:16212937}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008565 protein transporter activity
Biological Process
GO:0008535 respiratory chain complex IV assembly
GO:0015031 protein transport
GO:0051204 protein insertion into mitochondrial membrane
Cellular Component
GO:0031305 integral component of mitochondrial inner membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N8Q8
PhosphoSite PhosphoSite-Q8N8Q8
TrEMBL
UniProt Splice Variant
Entrez Gene 285521
UniGene Hs.707136
RefSeq
HUGO HGNC:26801
OMIM 610428
CCDS
HPRD 08249
IMGT
EMBL AK096310 AM055750 AM055751 AM055752 AY957564 AY957565 BC071812 BC101684
GenPept AAH71812 AAI01685 AAY35060 AAY35061 BAC04758 CAJ20055 CAJ20056 CAJ20057

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca