InnateDB Protein
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IDBP-480305.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ST3GAL6
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Protein Name
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ST3 beta-galactoside alpha-2,3-sialyltransferase 6
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Synonyms
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SIAT10; ST3GALVI;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000417376
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InnateDB Gene
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IDBG-46999 (ST3GAL6)
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Protein Structure
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Function |
Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3- sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0008373
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sialyltransferase activity
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GO:0052798
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beta-galactoside alpha-2,3-sialyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001675
Glycosyl transferase, family 29
IPR012163
Sialyltransferase
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PFAM |
PF00777
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PRINTS |
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PIRSF |
PIRSF005557
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y274
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PhosphoSite |
PhosphoSite-Q9Y274
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TrEMBL |
C9JXM2
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UniProt Splice Variant |
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Entrez Gene |
10402
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UniGene |
Hs.611523
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RefSeq |
NP_001258077
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HUGO |
HGNC:18080
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OMIM |
607156
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CCDS |
CCDS2933
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HPRD |
06195
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IMGT |
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EMBL |
AB022918
AC106728
AF119391
AK001922
AK315111
BC023312
CH471052
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GenPept |
AAD39131
AAH23312
BAA77609
BAG37569
BAG50993
EAW79849
EAW79850
EAW79852
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