InnateDB Protein
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IDBP-480468.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TACC2
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Protein Name
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transforming, acidic coiled-coil containing protein 2
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Synonyms
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AZU-1; ECTACC;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000425062
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InnateDB Gene
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IDBG-91710 (TACC2)
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Protein Structure
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Function |
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269PubMed:10749935}.
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Subcellular Localization |
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
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Disease Associations |
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Tissue Specificity |
Strongly expressed in heart, skeletal muscle, brain, prostate, thyroid and trachea. {ECO:0000269PubMed:11161455, ECO:0000269PubMed:12620397}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
25
[view]
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Protein-Protein |
25
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0035257
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nuclear hormone receptor binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007707
Transforming acidic coiled-coil
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PFAM |
PF05010
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O95359
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PhosphoSite |
PhosphoSite-O95359
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
10579
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UniGene |
Hs.501252
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RefSeq |
NP_996743
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HUGO |
HGNC:11523
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OMIM |
605302
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CCDS |
CCDS7625
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HPRD |
05600
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IMGT |
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EMBL |
AC063960
AF095791
AF176646
AF220152
AF528098
AF528099
AL135793
AL713712
BC000999
BC039311
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GenPept |
AAC64968
AAF29537
AAF63433
AAH00999
AAH39311
AAO62629
AAO62630
CAD28509
CAI95127
CAI95128
CAI95131
CAI95134
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