Version 5.4
Homo sapiens Protein: SPARC
Summary
InnateDB Protein IDBP-480522.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPARC
Protein Name secreted protein, acidic, cysteine-rich (osteonectin)
Synonyms ON;
Species Homo sapiens
Ensembl Protein ENSP00000428119
InnateDB Gene IDBG-54562 (SPARC)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 24 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0005578 proteinaceous extracellular matrix
Protein Structure and Domains
PDB ID
InterPro IPR002350 Kazal domain
IPR019577 SPARC/Testican, calcium-binding domain
PFAM PF00050
PF07648
PF10591
PRINTS
PIRSF
SMART SM00280
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E5RK62
UniProt Splice Variant
Entrez Gene 6678
UniGene Hs.706724
RefSeq
HUGO HGNC:11219
OMIM 182120
CCDS
HPRD 01631
IMGT
EMBL AC011374
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca