InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SPARC

Summary

InnateDB Gene

IDBG-54562.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPARC

Gene Name

secreted protein, acidic, cysteine-rich (osteonectin)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000113140

Encoded Proteins

IDBP-54564

secreted protein, acidic, cysteine-rich (osteonectin)

IDBP-480522

secreted protein, acidic, cysteine-rich (osteonectin)

IDBP-482573

secreted protein, acidic, cysteine-rich (osteonectin)

IDBP-585344

secreted protein, acidic, cysteine-rich (osteonectin)

IDBP-602219

secreted protein, acidic, cysteine-rich (osteonectin)

IDBP-806883

secreted protein, acidic, cysteine-rich (osteonectin)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:151661096-151687165

Strand

Reverse strand

Band

q33.1

Transcripts

ENST00000231061	ENSP00000231061
ENST00000520687
ENST00000521569	ENSP00000428119
ENST00000524277
ENST00000521327
ENST00000522348	ENSP00000429152
ENST00000538026	ENSP00000440127
ENST00000537849
ENST00000539687	ENSP00000444998
ENST00000620972	ENSP00000480550

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0050840	extracellular matrix binding

Biological Process

GO:0001503	ossification
GO:0002576	platelet degranulation
GO:0007165	signal transduction
GO:0007507	heart development
GO:0007596	blood coagulation
GO:0009629	response to gravity
GO:0010288	response to lead ion
GO:0030168	platelet activation
GO:0030198	extracellular matrix organization
GO:0030324	lung development
GO:0032496	response to lipopolysaccharide
GO:0033591	response to L-ascorbic acid
GO:0034097	response to cytokine
GO:0042060	wound healing
GO:0042127	regulation of cell proliferation
GO:0043434	response to peptide hormone
GO:0045471	response to ethanol
GO:0046686	response to cadmium ion
GO:0048839	inner ear development
GO:0051384	response to glucocorticoid
GO:0051591	response to cAMP
GO:0051592	response to calcium ion
GO:0060348	bone development
GO:0071363	cellular response to growth factor stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0031012	extracellular matrix
GO:0031093	platelet alpha granule lumen
GO:0031988	membrane-bounded vesicle
GO:0071682	endocytic vesicle lumen