Version 5.4
Homo sapiens Protein: SORCS2
Summary
InnateDB Protein IDBP-480618.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SORCS2
Protein Name sortilin-related VPS10 domain containing receptor 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000422185
InnateDB Gene IDBG-9263 (SORCS2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Highly expressed in brain and kidney. Detected at low levels in heart, liver, small intestine, skeletal muscle and thymus.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008188 neuropeptide receptor activity
Biological Process
GO:0007218 neuropeptide signaling pathway
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000601 PKD domain
IPR006581 VPS10
IPR022409 PKD/Chitinase domain
PFAM PF00801
PRINTS
PIRSF
SMART SM00602
SM00089
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96PQ0
PhosphoSite PhosphoSite-Q96PQ0
TrEMBL
UniProt Splice Variant
Entrez Gene 57537
UniGene Hs.609952
RefSeq NP_065828
HUGO HGNC:16698
OMIM 606284
CCDS CCDS47008
HPRD 12099
IMGT
EMBL AB037750 AC004169 AC080003 AC097382 AC112710 AC116316 AF286190
GenPept AAL04014 BAA92567

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca