Version 5.4
Homo sapiens Protein: GIMAP1
Summary
InnateDB Protein IDBP-48068.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GIMAP1
Protein Name GTPase, IMAP family member 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000302833
InnateDB Gene IDBG-244803 (GIMAP1)
Protein Structure
UniProt Annotation
Function May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Golgi apparatus membrane {ECO:0000250}. Golgi apparatus {ECO:0000305}.
Disease Associations
Tissue Specificity Predominantly expressed in the spleen and to a lesser extent in the lymph nodes. Detected in T-cells. {ECO:0000269PubMed:11814688, ECO:0000269PubMed:23454188}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005525 GTP binding
Biological Process
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR006703 AIG1
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF04548
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WWP7
PhosphoSite PhosphoSite-Q8WWP7
TrEMBL
UniProt Splice Variant
Entrez Gene 170575
UniGene Hs.647079
RefSeq NP_570115
HUGO HGNC:23237
OMIM 608084
CCDS CCDS5906
HPRD 16278
IMGT
EMBL AJ306287 AK091818 AK315127 BC040736 CH471173
GenPept AAH40736 BAC03754 BAG37580 CAC83740 EAW54095

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca