InnateDB Protein
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IDBP-480684.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RERE
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Protein Name
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arginine-glutamic acid dipeptide (RE) repeats
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Synonyms
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ARG; ARP; ATN1L; DNB1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000422246
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InnateDB Gene
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IDBG-88369 (RERE)
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Protein Structure
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Function |
Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. {ECO:0000269PubMed:11331249}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00512, ECO:0000255PROSITE-ProRule:PRU00624, ECO:0000269PubMed:10814707, ECO:0000269PubMed:11331249}. Note=Localized in nuclear bodies of variables size. Colocalized with PML and BAX in nuclear PODs.
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Disease Associations |
Note=A chromosomal aberration involving RERE is found in the neuroblastoma cell line NGP. Translocation t(1;15)(p36.2;q24).
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Tissue Specificity |
Widely expressed. Expressed in tumor cell lines. {ECO:0000269PubMed:10729226, ECO:0000269PubMed:10814707, ECO:0000269PubMed:11331249}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
25
[view]
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Protein-Protein |
24
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002951
Atrophin-like
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PFAM |
PF03154
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9P2R6
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PhosphoSite |
PhosphoSite-Q9P2R6
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TrEMBL |
K7EIQ4
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UniProt Splice Variant |
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Entrez Gene |
473
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UniGene |
Hs.701637
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RefSeq |
NP_001036147
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HUGO |
HGNC:9965
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OMIM |
605226
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CCDS |
CCDS41243
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HPRD |
05566
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IMGT |
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EMBL |
AB007927
AB036737
AF016005
AF041096
AF041097
AF041098
AF041099
AF041100
AF041101
AF041102
AF041103
AF041104
AF118275
AL096855
AL356072
AL357552
AL357713
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GenPept |
AAC28264
AAC31120
AAD27584
BAA32303
BAA95898
CAH70516
CAH73433
CAI19208
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