Version 5.4
Homo sapiens Gene: RERE
Summary
InnateDB Gene IDBG-88369.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RERE
Gene Name arginine-glutamic acid dipeptide (RE) repeats
Synonyms ARG; ARP; ATN1L; DNB1
Species Homo sapiens
Ensembl Gene ENSG00000142599
Encoded Proteins
IDBP-88371
arginine-glutamic acid dipeptide (RE) repeats
IDBP-88373
arginine-glutamic acid dipeptide (RE) repeats
IDBP-227113
arginine-glutamic acid dipeptide (RE) repeats
IDBP-227115
arginine-glutamic acid dipeptide (RE) repeats
IDBP-480684
arginine-glutamic acid dipeptide (RE) repeats
IDBP-479395
arginine-glutamic acid dipeptide (RE) repeats
IDBP-721977
IDBP-721821
IDBP-721958
IDBP-481727
arginine-glutamic acid dipeptide (RE) repeats
IDBP-722165
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:8352397-8817643
Strand Reverse strand
Band p36.23
Transcripts
ENST00000337907 ENSP00000338629
ENST00000377464 ENSP00000366684
ENST00000400908 ENSP00000383700
ENST00000400907 ENSP00000383699
ENST00000467350
ENST00000476556 ENSP00000422246
ENST00000505225 ENSP00000423451
ENST00000464367 ENSP00000465133
ENST00000488215 ENSP00000464847
ENST00000460659
ENST00000492766
ENST00000465125
ENST00000464972 ENSP00000464712
ENST00000480342
ENST00000507012
ENST00000469251
ENST00000514428 ENSP00000423259
ENST00000468247 ENSP00000465271
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008267 poly-glutamine tract binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006607 NLS-bearing protein import into nucleus
GO:0007275 multicellular organismal development
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039852
View Gene Order
ENSBTAG00000018272
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.463041 Hs.700009 Hs.701637
RefSeq NM_001042681 NM_001042682 NM_012102 XM_005263464 XM_005263465 XM_005263466 XM_006710653 XM_006710654
HUGO
OMIM
CCDS CCDS41243 CCDS95
HPRD 05566
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca