InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ELF2

Summary

InnateDB Protein

IDBP-480733.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ELF2

Protein Name

E74-like factor 2 (ets domain transcription factor)

Synonyms

EU32; NERF; NERF-1A; NERF-1a,b; NERF-1B; NERF-2;

Species

Homo sapiens

Ensembl Protein

ENSP00000426997

InnateDB Gene

IDBG-38206 (ELF2)

Protein Structure

UniProt Annotation

Function

Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.Isoform 2 may function in repression of RUNX1-mediated transactivation.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in all fetal and adult tissues examined. Among fetal tissues, highest levels of expression detected in heart, lung, liver and kidney, and lower levels in brain. Among adult tissues, highest levels of expression detected in heart, placenta, lung, skeletal muscle, spleen, thymus, testis and ovary. Moderate expression in prostate, small intestine, kidney, liver and pancreas, and weak expression in colon, brain and peripheral blood lymphocytes. {ECO:0000269PubMed:8756667}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	7 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0030154	cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated