InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TFAM

Summary

InnateDB Protein

IDBP-480746.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TFAM

Protein Name

transcription factor A, mitochondrial

Synonyms

MTTF1; MTTFA; TCF6; TCF6L1; TCF6L2; TCF6L3;

Species

Homo sapiens

Ensembl Protein

ENSP00000420588

InnateDB Gene

IDBG-74965 (TFAM)

Protein Structure

UniProt Annotation

Function

Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA. {ECO:0000269PubMed:1737790, ECO:0000269PubMed:19304746, ECO:0000269PubMed:20410300, ECO:0000269PubMed:22037171, ECO:0000269PubMed:22037172, ECO:0000269PubMed:22841477}.

Subcellular Localization

Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	19 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008301	DNA binding, bending
GO:0031072	heat shock protein binding
GO:0044822	poly(A) RNA binding
GO:0070363	mitochondrial light strand promoter sense binding

Biological Process

GO:0006261	DNA-dependent DNA replication
GO:0006356	regulation of transcription from RNA polymerase I promoter
GO:0006390	transcription from mitochondrial promoter
GO:0006391	transcription initiation from mitochondrial promoter
GO:0010467	gene expression
GO:0033108	mitochondrial respiratory chain complex assembly
GO:0045893	positive regulation of transcription, DNA-templated