InnateDB Protein
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IDBP-480765.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MLF1
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Protein Name
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myeloid leukemia factor 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000420134
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InnateDB Gene
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IDBG-63091 (MLF1)
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Protein Structure
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Function |
Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. {ECO:0000269PubMed:15861129}.
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Subcellular Localization |
Cytoplasm. Nucleus. Note=In non- hematopoietic cells, resides primarily in the cytoplasm with some punctate nuclear localization. Shuttles between the cytoplasm and nucleus. In hematopoietic cells, located preferentially in the nucleus. Found in the nucleolus when fused to NPM.
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Disease Associations |
Note=A chromosomal aberration involving MLF1 is a cause of myelodysplastic syndrome (MDS). Translocation t(3;5)(q25.1;q34) with NPM1/NPM.
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Tissue Specificity |
Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
66
[view]
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Protein-Protein |
65
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR019376
Myeloid leukemia factor
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PFAM |
PF10248
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P58340
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PhosphoSite |
PhosphoSite-P58340
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TrEMBL |
C9K0D3
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UniProt Splice Variant |
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Entrez Gene |
4291
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UniGene |
Hs.605551
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RefSeq |
NP_001182363
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HUGO |
HGNC:7125
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OMIM |
601402
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CCDS |
CCDS56287
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HPRD |
03239
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IMGT |
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EMBL |
AC025033
AC106707
AK056948
AK096889
AK297488
AY848700
AY848702
BC007045
CH471052
L49054
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GenPept |
AAA99997
AAH07045
AAX46015
AAX46017
BAB71320
BAC04885
BAG59906
EAW78689
EAW78690
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