InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EIF2A

Summary

InnateDB Protein

IDBP-480848.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF2A

Protein Name

eukaryotic translation initiation factor 2A, 65kDa

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000417229

InnateDB Gene

IDBG-61199 (EIF2A)

Protein Structure

UniProt Annotation

Function

Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF- 2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon- dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins. {ECO:0000269PubMed:12133843}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed. Expressed at higher level in pancreas, heart, brain and placenta. {ECO:0000269PubMed:12133843}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000049	tRNA binding
GO:0003743	translation initiation factor activity
GO:0005515	protein binding
GO:0043022	ribosome binding

Biological Process

GO:0006412	translation
GO:0006413	translational initiation
GO:0006417	regulation of translation
GO:0006468	protein phosphorylation
GO:0009967	positive regulation of signal transduction
GO:0032933	SREBP signaling pathway
GO:0042255	ribosome assembly