Homo sapiens Gene: EIF2A
Summary
InnateDB Gene IDBG-61199.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF2A
Gene Name eukaryotic translation initiation factor 2A, 65kDa
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000144895
Encoded Proteins
eukaryotic translation initiation factor 2A, 65kDa
eukaryotic translation initiation factor 2A, 65kDa
eukaryotic translation initiation factor 2A, 65kDa
eukaryotic translation initiation factor 2A, 65kDa
eukaryotic translation initiation factor 2A, 65kDa
eukaryotic translation initiation factor 2A, 65kDa
eukaryotic translation initiation factor 2A, 65kDa
eukaryotic translation initiation factor 2A, 65kDa
eukaryotic translation initiation factor 2A, 65kDa
eukaryotic translation initiation factor 2A, 65kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002 [PubMed 12133843]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:150546678-150584242
Strand Forward strand
Band q25.1
Transcripts
ENST00000273435 ENSP00000273435
ENST00000406576 ENSP00000385292
ENST00000463863
ENST00000487799 ENSP00000420537
ENST00000460851 ENSP00000417229
ENST00000473499
ENST00000494558 ENSP00000419456
ENST00000474505
ENST00000482093 ENSP00000418698
ENST00000469331
ENST00000490505 ENSP00000417575
ENST00000462221 ENSP00000420495
ENST00000477551 ENSP00000420493
ENST00000472926
ENST00000465535 ENSP00000420611
ENST00000482471
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0043022 ribosome binding
Biological Process
GO:0006412 translation
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0006468 protein phosphorylation
GO:0009967 positive regulation of signal transduction
GO:0032933 SREBP signaling pathway
GO:0042255 ribosome assembly
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005850 eukaryotic translation initiation factor 2 complex
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
IL6 pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
TGF-beta receptor signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 83939
UniGene Hs.655782
RefSeq NM_032025
HUGO HGNC:3254
OMIM 609234
CCDS CCDS46935
HPRD 11739
IMGT
EMBL
GenPept
RNA Seq Atlas 83939