InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FBXL2

Summary

InnateDB Protein

IDBP-481027.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXL2

Protein Name

F-box and leucine-rich repeat protein 2

Synonyms

FBL2; FBL3;

Species

Homo sapiens

Ensembl Protein

ENSP00000417601

InnateDB Gene

IDBG-24091 (FBXL2)

Protein Structure

UniProt Annotation

Function

Calcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 doesn't seem to target phosphodegron within its substrates but rather calmodulin-binding motifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized by calmodulin (By similarity). Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation, leading to cell-cycle arrest in G(0), also antagonized by calmodulin. Binds to hepatitis C virus non-structural protein 5A (NS5A) in a reaction crucial for hepatitis C virus RNA replication. {ECO:0000250, ECO:0000269PubMed:15893726, ECO:0000269PubMed:22020328, ECO:0000269PubMed:22323446}.

Subcellular Localization

Membrane {ECO:0000269PubMed:15893726}; Lipid-anchor {ECO:0000269PubMed:15893726}.

Disease Associations

Tissue Specificity

Expressed in brain, heart, kidney, liver, lung, pancreas and placenta. {ECO:0000269PubMed:10531037}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding

Biological Process

GO:0006464	cellular protein modification process
GO:0006508	proteolysis
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006513	protein monoubiquitination
GO:0016032	viral process