Homo sapiens Gene: FBXL2
Summary
InnateDB Gene IDBG-24091.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXL2
Gene Name F-box and leucine-rich repeat protein 2
Synonyms FBL2; FBL3
Species Homo sapiens
Ensembl Gene ENSG00000153558
Encoded Proteins
F-box and leucine-rich repeat protein 2
F-box and leucine-rich repeat protein 2
F-box and leucine-rich repeat protein 2
F-box and leucine-rich repeat protein 2
F-box and leucine-rich repeat protein 2
F-box and leucine-rich repeat protein 2
F-box and leucine-rich repeat protein 2
F-box and leucine-rich repeat protein 2
F-box and leucine-rich repeat protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:33277025-33403662
Strand Forward strand
Band p22.3
Transcripts
ENST00000283627
ENST00000435207 ENSP00000411484
ENST00000432809 ENSP00000411273
ENST00000451636 ENSP00000416332
ENST00000425973 ENSP00000405084
ENST00000422741 ENSP00000406737
ENST00000421391 ENSP00000408895
ENST00000498807
ENST00000484457 ENSP00000417601
ENST00000497411
ENST00000463736
ENST00000507198 ENSP00000426163
ENST00000483037
ENST00000493778
ENST00000464164
ENST00000461094
ENST00000463698
ENST00000460186
ENST00000492662
ENST00000471208
ENST00000464990
ENST00000538892 ENSP00000441228
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
Biological Process
GO:0006464 cellular protein modification process
GO:0006508 proteolysis
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006513 protein monoubiquitination
GO:0016032 viral process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.475872 Hs.614859
RefSeq NM_001171713 NM_012157 XM_005265017
HUGO
OMIM
CCDS CCDS2658 CCDS54560
HPRD 05736
IMGT
EMBL
GenPept
RNA Seq Atlas