Homo sapiens Protein: ARHGEF26 | |||||||
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Summary | |||||||
InnateDB Protein | IDBP-481239.4 | ||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
Gene Symbol | ARHGEF26 | ||||||
Protein Name | Rho guanine nucleotide exchange factor (GEF) 26 | ||||||
Synonyms | CSGEF; HMFN1864; SGEF; | ||||||
Species | Homo sapiens | ||||||
Ensembl Protein | ENSP00000423418 | ||||||
InnateDB Gene | IDBG-61957 (ARHGEF26) | ||||||
Protein Structure | |||||||
UniProt Annotation | |||||||
Function | Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269PubMed:15133129, ECO:0000269PubMed:17074883, ECO:0000269PubMed:17875742}. | ||||||
Subcellular Localization | Cell projection, ruffle {ECO:0000269PubMed:15133129, ECO:0000269PubMed:17875742}. | ||||||
Disease Associations | |||||||
Tissue Specificity | Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver. {ECO:0000269PubMed:12697679, ECO:0000269PubMed:15133129}. | ||||||
Comments | |||||||
Interactions | |||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||
PDB ID | |||||||
InterPro |
IPR000219
Dbl homology (DH) domain IPR001452 SH3 domain IPR001849 Pleckstrin homology domain IPR011511 Variant SH3 domain |
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PFAM |
PF00621
PF00018 PF14604 PF00169 PF07653 |
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PRINTS |
PR00452
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PIRSF | |||||||
SMART |
SM00325
SM00326 SM00233 |
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TIGRFAMs | |||||||
Post-translational Modifications | |||||||
Modification | |||||||
Cross-References | |||||||
SwissProt | Q96DR7 | ||||||
PhosphoSite | PhosphoSite-Q96DR7 | ||||||
TrEMBL | |||||||
UniProt Splice Variant | |||||||
Entrez Gene | 26084 | ||||||
UniGene | Hs.608994 | ||||||
RefSeq | NP_056410 | ||||||
HUGO | HGNC:24490 | ||||||
OMIM | |||||||
CCDS | CCDS46938 | ||||||
HPRD | 11554 | ||||||
IMGT | |||||||
EMBL | AB073386 AC018452 AF415175 AF415176 AK022655 AK022884 AK123040 AL117429 AY552599 BC016628 BC078655 FJ695204 | ||||||
GenPept | AAH16628 AAH78655 AAL27001 AAL27002 AAS59842 BAB14159 BAB14292 BAD38637 BAG53860 CAB55918 | ||||||