InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLKB1

Summary

InnateDB Protein

IDBP-481314.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLKB1

Protein Name

kallikrein B, plasma (Fletcher factor) 1

Synonyms

KLK3; PPK;

Species

Homo sapiens

Ensembl Protein

ENSP00000426629

InnateDB Gene

IDBG-47494 (KLKB1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding

Biological Process

GO:0006508	proteolysis
GO:0007596	blood coagulation
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005576

extracellular region

Protein Structure and Domains

PDB ID

InterPro

IPR000177 Apple domain
IPR001128 Cytochrome P450
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
IPR003014 PAN-1 domain
IPR003609 Apple-like
IPR009003 Trypsin-like cysteine/serine peptidase domain

PFAM

PF00067
PF00089
PF00024

PRINTS

PR00005
PR00385
PR00722
PR00463
PR00465

PIRSF

SMART

SM00223
SM00020
SM00473

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt