InnateDB Protein
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IDBP-481410.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ST3GAL1
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Protein Name
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ST3 beta-galactoside alpha-2,3-sialyltransferase 1
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Synonyms
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Gal-NAc6S; SIAT4A; SIATFL; ST3GalA; ST3GalA.1; ST3GalIA; ST3GalIA,1; ST3O;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000428540
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InnateDB Gene
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IDBG-36530 (ST3GAL1)
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Protein Structure
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Function |
It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O- linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values.
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Subcellular Localization |
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid.
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Disease Associations |
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Tissue Specificity |
Expressed in several tissues. Highest expression in lung, liver, skeletal muscle, kidney, pancreas, spleen and placenta.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003836
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beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
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GO:0008373
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sialyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001675
Glycosyl transferase, family 29
IPR012163
Sialyltransferase
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PFAM |
PF00777
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PRINTS |
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PIRSF |
PIRSF005557
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q11201
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PhosphoSite |
PhosphoSite-
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TrEMBL |
E5RHV6
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UniProt Splice Variant |
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Entrez Gene |
6482
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UniGene |
Hs.736266
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RefSeq |
NP_775479
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HUGO |
HGNC:10862
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OMIM |
607187
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CCDS |
CCDS6373
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HPRD |
06219
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IMGT |
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EMBL |
AC103706
AF059321
AF186191
BC018357
CH471060
L13972
L29555
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GenPept |
AAA36612
AAC17874
AAC37574
AAH18357
EAW92172
EAW92173
EAW92174
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