Version 5.4
Homo sapiens Protein: MMEL1
Summary
InnateDB Protein IDBP-481490.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MMEL1
Protein Name membrane metallo-endopeptidase-like 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000422492
InnateDB Gene IDBG-86465 (MMEL1)
Protein Structure
UniProt Annotation
Function Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity). {ECO:0000250}.
Subcellular Localization Membrane; Single-pass type II membrane protein. Secreted. Note=A secreted form produced by proteollytic cleavage also exists. {ECO:0000250}.
Disease Associations
Tissue Specificity Predominantly expressed in testis. Weakly expressed in brain, kidney and heart. {ECO:0000269PubMed:11560781}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR008753 Peptidase M13, N-terminal domain
IPR018497 Peptidase M13, C-terminal domain
PFAM PF05649
PF01431
PRINTS PR00786
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q495T6
PhosphoSite PhosphoSite-Q495T6
TrEMBL
UniProt Splice Variant
Entrez Gene 79258
UniGene Hs.591453
RefSeq
HUGO HGNC:14668
OMIM
CCDS
HPRD 07024
IMGT
EMBL AF336981 AL139246 AL589746 AL831784 BC101027 BC101028 BC101029 BC101030 CH471183
GenPept AAI01028 AAI01029 AAI01030 AAI01031 AAL08942 CAI17336 CAI22652 CAX30814 EAW56082

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca