InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EPB49

Summary

InnateDB Protein

IDBP-481583.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPB49

Protein Name

erythrocyte membrane protein band 4.9 (dematin)

Synonyms

DMT; EPB49;

Species

Homo sapiens

Ensembl Protein

ENSP00000430609

InnateDB Gene

IDBG-10014 (EPB49)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0030507	spectrin binding
GO:0043621	protein self-association

Biological Process

GO:0006461	protein complex assembly
GO:0007010	cytoskeleton organization
GO:0008360	regulation of cell shape
GO:0010591	regulation of lamellipodium assembly
GO:0010763	positive regulation of fibroblast migration
GO:0010801	negative regulation of peptidyl-threonine phosphorylation
GO:0010812	negative regulation of cell-substrate adhesion
GO:0030036	actin cytoskeleton organization
GO:0030194	positive regulation of blood coagulation
GO:0032956	regulation of actin cytoskeleton organization
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0035584	calcium-mediated signaling using intracellular calcium source
GO:0035585	calcium-mediated signaling using extracellular calcium source
GO:0048821	erythrocyte development
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
GO:0051017	actin filament bundle assembly
GO:0051489	regulation of filopodium assembly
GO:0051693	actin filament capping
GO:0051895	negative regulation of focal adhesion assembly
GO:0070560	protein secretion by platelet
GO:0071277	cellular response to calcium ion
GO:0071320	cellular response to cAMP
GO:0090303	positive regulation of wound healing
GO:0090315	negative regulation of protein targeting to membrane
GO:0090527	actin filament reorganization
GO:1900025	negative regulation of substrate adhesion-dependent cell spreading
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading
GO:1901731	positive regulation of platelet aggregation
GO:2001046	positive regulation of integrin-mediated signaling pathway

Cellular Component

GO:0005829	cytosol
GO:0005884	actin filament
GO:0005886	plasma membrane
GO:0012505	endomembrane system
GO:0014731	spectrin-associated cytoskeleton
GO:0015629	actin cytoskeleton
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0031095	platelet dense tubular network membrane
GO:0031253	cell projection membrane
GO:0048471	perinuclear region of cytoplasm