InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EPB49

Summary

InnateDB Gene

IDBG-10014.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPB49

Gene Name

erythrocyte membrane protein band 4.9 (dematin)

Synonyms

DMT; EPB49

Species

Homo sapiens

Ensembl Gene

ENSG00000158856

Encoded Proteins

IDBP-10016

erythrocyte membrane protein band 4.9 (dematin)

IDBP-10018

erythrocyte membrane protein band 4.9 (dematin)

IDBP-10020

erythrocyte membrane protein band 4.9 (dematin)

IDBP-362362

erythrocyte membrane protein band 4.9 (dematin)

IDBP-362363

erythrocyte membrane protein band 4.9 (dematin)

IDBP-362374

erythrocyte membrane protein band 4.9 (dematin)

IDBP-474510

erythrocyte membrane protein band 4.9 (dematin)

IDBP-483440

erythrocyte membrane protein band 4.9 (dematin)

IDBP-479503

erythrocyte membrane protein band 4.9 (dematin)

IDBP-483513

erythrocyte membrane protein band 4.9 (dematin)

IDBP-475255

erythrocyte membrane protein band 4.9 (dematin)

IDBP-475084

erythrocyte membrane protein band 4.9 (dematin)

IDBP-480178

erythrocyte membrane protein band 4.9 (dematin)

IDBP-478144

erythrocyte membrane protein band 4.9 (dematin)

IDBP-483434

erythrocyte membrane protein band 4.9 (dematin)

IDBP-479947

erythrocyte membrane protein band 4.9 (dematin)

IDBP-480575

erythrocyte membrane protein band 4.9 (dematin)

IDBP-481583

erythrocyte membrane protein band 4.9 (dematin)

IDBP-807846

dematin actin binding protein

IDBP-807847

dematin actin binding protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Dematin, or EPB49, is an actin-bundling protein originally identified in the erythroid membrane skeleton. Its actin-bundling activity is abolished upon phosphorylation by cAMP-dependent protein kinase and is restored after dephosphorylation (Rana et al., 1993 [PubMed 8341682]).[supplied by OMIM, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:22048995-22082527

Strand

Forward strand

Band

p21.3

Transcripts

ENST00000358242	ENSP00000350977
ENST00000381470	ENSP00000370879
ENST00000265800	ENSP00000265800
ENST00000432128	ENSP00000416111
ENST00000443491	ENSP00000397904
ENST00000415253	ENSP00000401291
ENST00000522148	ENSP00000428063
ENST00000523300	ENSP00000429116
ENST00000519959
ENST00000519850	ENSP00000430600
ENST00000518816
ENST00000517600	ENSP00000430618
ENST00000523782	ENSP00000429234
ENST00000520856
ENST00000523623	ENSP00000428733
ENST00000520174	ENSP00000430382
ENST00000517804	ENSP00000428415
ENST00000517418	ENSP00000429948
ENST00000523266	ENSP00000427866
ENST00000519907	ENSP00000429377
ENST00000517305	ENSP00000430609
ENST00000522340	ENSP00000477684
ENST00000519333	ENSP00000478536

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0030507	spectrin binding
GO:0043621	protein self-association

Biological Process

GO:0006461	protein complex assembly
GO:0007010	cytoskeleton organization
GO:0008360	regulation of cell shape
GO:0010591	regulation of lamellipodium assembly
GO:0010763	positive regulation of fibroblast migration
GO:0010801	negative regulation of peptidyl-threonine phosphorylation
GO:0010812	negative regulation of cell-substrate adhesion
GO:0030036	actin cytoskeleton organization
GO:0030194	positive regulation of blood coagulation
GO:0032956	regulation of actin cytoskeleton organization
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0035584	calcium-mediated signaling using intracellular calcium source
GO:0035585	calcium-mediated signaling using extracellular calcium source
GO:0048821	erythrocyte development
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
GO:0051017	actin filament bundle assembly
GO:0051489	regulation of filopodium assembly
GO:0051693	actin filament capping
GO:0051895	negative regulation of focal adhesion assembly
GO:0070560	protein secretion by platelet
GO:0071277	cellular response to calcium ion
GO:0071320	cellular response to cAMP
GO:0090303	positive regulation of wound healing
GO:0090315	negative regulation of protein targeting to membrane
GO:0090527	actin filament reorganization
GO:1900025	negative regulation of substrate adhesion-dependent cell spreading
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading
GO:1901731	positive regulation of platelet aggregation
GO:2001046	positive regulation of integrin-mediated signaling pathway

Cellular Component

GO:0005829	cytosol
GO:0005884	actin filament
GO:0005886	plasma membrane
GO:0012505	endomembrane system
GO:0014731	spectrin-associated cytoskeleton
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030863	cortical cytoskeleton
GO:0031095	platelet dense tubular network membrane
GO:0031253	cell projection membrane
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022099

View Gene Order

ENSBTAG00000045887

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.106124 Hs.595894

RefSeq

NM_001114135 NM_001114136 NM_001114137 NM_001114138 NM_001114139 NM_001978 XM_005273431 XM_005273432 XM_005273433 XM_005273434 XM_005273438 XM_005273440 XM_005273442 XM_005273444 XM_006716300

HUGO

OMIM

CCDS

CCDS47820 CCDS47821 CCDS6020

HPRD

00506

IMGT

EMBL

GenPept

RNA Seq Atlas